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. 2015 Jun 11;6(7):814–818. doi: 10.1021/acsmedchemlett.5b00176

Table 3. Antitubercular Activity of Compounds 5g, 5k, 5p, and 5t against Drug-Resistant Clinical Mtb Isolates.

    MIC (nM)b
strains resistancea 5g 5k 5p 5t
3495 HRSZ 1914 22.3–223 n.d.c n.d.
P71 HRZ <383 11.1–223 <184 71.8–1795
9804 HRZ <383 <11.1 <184 <35.9
4768 EHRSZ <383 11.1–223 <184 35.9–71.8
P163 EHSZ <383 11.1–223 <184 <35.9
a

H, isoniazid; R, rifampicin; S, streptomycin; E, ethambutol; Z, pyrazinamide.

b

Values are means of two independent experiments, and the variation is <20%.

c

Not determined.