Table 3. Antitubercular Activity of Compounds 5g, 5k, 5p, and 5t against Drug-Resistant Clinical Mtb Isolates.
MIC (nM)b |
|||||
---|---|---|---|---|---|
strains | resistancea | 5g | 5k | 5p | 5t |
3495 | HRSZ | 1914 | 22.3–223 | n.d.c | n.d. |
P71 | HRZ | <383 | 11.1–223 | <184 | 71.8–1795 |
9804 | HRZ | <383 | <11.1 | <184 | <35.9 |
4768 | EHRSZ | <383 | 11.1–223 | <184 | 35.9–71.8 |
P163 | EHSZ | <383 | 11.1–223 | <184 | <35.9 |
H, isoniazid; R, rifampicin; S, streptomycin; E, ethambutol; Z, pyrazinamide.
Values are means of two independent experiments, and the variation is <20%.
Not determined.