Table 4. EP Evaluation of Selected Inhibitors.
| 6 | 23 | 28 | 35 | 41 | 46 | 50 | |
|---|---|---|---|---|---|---|---|
| ROMK EP IC50 (nM) | 64 | 18 | 27 | 12 | 54 | 40 | 13 |
| hERG EP IC50 (μM) | 4.5 | 12 | 33 | 14 | 14 | 12 | 30 |
| hERG/ROMK | 70 | 667 | 1222 | 1166 | 254 | 300 | 2307 |
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