Table 5. SD Rat PK for Selected ROMK Inhibitors.
6 | 23 | 28 | 35 | 50 | |
---|---|---|---|---|---|
Cl (L/kg) | 40 | 23 | 31 | 25 | 58 |
AUCNpo (μM h kg/mg) | 0.34 | 1.6 | 0.84 | 1.3 | 1.2 |
t1/2 (h) | 0.62 | 2.0 | 1.6 | 1.4 | 1.5 |
Fpo (%) | 33 | 96 | 65 | 81 | 91 |
6 | 23 | 28 | 35 | 50 | |
---|---|---|---|---|---|
Cl (L/kg) | 40 | 23 | 31 | 25 | 58 |
AUCNpo (μM h kg/mg) | 0.34 | 1.6 | 0.84 | 1.3 | 1.2 |
t1/2 (h) | 0.62 | 2.0 | 1.6 | 1.4 | 1.5 |
Fpo (%) | 33 | 96 | 65 | 81 | 91 |