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. 2015 May 7;6(7):747–752. doi: 10.1021/ml500440u

Table 8. Twenty-Four Hour Diuresis/Natriuresis of (R,S)-28 in Dogs.

dose (mpk) 0.1 0.3 1 3 10
AUC (μM·h) 0.081 0.51 1.1 5.0 15
diuresisa 1.1 1.7 2.1 2.8 4.5
natriuresisa 1.0 1.5 1.6 1.5 2.6
kaliuresisa 1.0 0.88 0.60 0.78 1.0
a

Fold increase compared to vehicle; n = 6 per group.