Table 2.
Comparison of urinary phthalate metabolites in study population with blood pressure data in pooled 2009–2012 NHANES (n=1329)
| Characteristics | Mean urinary LMW metabolite (µmolar) |
p value* | Mean urinary HMW metabolite (µmolar) |
p value | Mean urinary DEHP metabolite (µmolar) |
p value* | Mean urinary DIDP metabolite (µmolar) |
p value | Mean urinary DINP metabolite (µmolar) |
p value |
|---|---|---|---|---|---|---|---|---|---|---|
| Sex | ||||||||||
| Male | 0.379 | Ref. | 0.387 | Ref. | 0.195 | Ref. | 0.009 | Ref. | 0.071 | Ref. |
| Female | 0.479 | 0.003 | 0.397 | 0.85 | 0.194 | 0.96 | 0.010 | 0.68 | 0.077 | 0.58 |
| Age group, y | ||||||||||
| 6–11 | 0.593 | Ref. | 0.514 | Ref. | 0.241 | Ref. | 0.013 | Ref. | 0.103 | Ref. |
| 12–19 | 0.511 | 0.16 | 0.357 | 0.002 | 0.174 | 0.011 | 0.009 | <0.001 | 0.072 | 0.01 |
| Race/ethnicity | ||||||||||
| Hispanic-Mexican American | 0.631 | Ref. | 0.404 | Ref. | 0.208 | Ref. | 0.009 | Ref. | 0.065 | Ref. |
| Hispanic-Other Hispanic | 0.332 | 0.001 | 0.416 | 0.84 | 0.196 | 0.77 | 0.011 | 0.008 | 0.081 | 0.15 |
| Non-Hispanic White | 0.442 | 0.001 | 0.417 | 0.80 | 0.194 | 0.60 | 0.011 | 0.06 | 0.093 | 0.046 |
| Non-Hispanic Black | 0.779 | 0.07 | 0.336 | 0.17 | 0.172 | 0.18 | 0.009 | 0.54 | 0.057 | 0.42 |
| Other | 0.528 | 0.43 | 0.417 | 0.85 | 0.205 | 0.95 | 0.008 | 0.73 | 0.080 | 0.30 |
| Poverty-income ratio | ||||||||||
| First quartile (< 0.83) | 0.666 | Ref. | 0.413 | Ref. | 0.204 | Ref. | 0.009 | Ref. | 0.073 | Ref. |
| Second quartile (0.83 to 1.59) | 0.619 | 0.73 | 0.446 | 0.58 | 0.219 | 0.64 | 0.010 | 0.51 | 0.076 | 0.86 |
| Third quartile (1.60 to 3.09) | 0.568 | 0.40 | 0.387 | 0.62 | 0.178 | 0.17 | 0.010 | 0.60 | 0.079 | 0.73 |
| Fourth quartile (at least 3.1) | 0.451 | 0.032 | 0.411 | 0.98 | 0.199 | 0.87 | 0.011 | 0.21 | 0.089 | 0.42 |
| Missing | 0.527 | 0.42 | 0.326 | 0.20 | 0.158 | 0.25 | 0.008 | 0.65 | 0.071 | 0.91 |
| Serum cotinine | ||||||||||
| Less than 0.015 ng/mL | 0.469 | Ref. | 0.356 | Ref. | 0.171 | Ref. | 0.010 | Ref. | 0.081 | Ref. |
| 0.015–1.9 ng/mL | 0.560 | 0.022 | 0.420 | 0.07 | 0.208 | 0.041 | 0.010 | 0.49 | 0.078 | 0.80 |
| At least 2.0 ng/mL | 0.659 | 0.013 | 0.366 | 0.85 | 0.166 | 0.81 | 0.008 | 0.14 | 0.079 | 0.91 |
| Missing | 0.423 | 0.54 | 0.450 | 0.17 | 0.194 | 0.50 | 0.015 | 0.028 | 0.096 | 0.35 |
| Physical activity | ||||||||||
| Insufficient (<60min/day) | 0.147 | Ref. | 0.167 | Ref. | 0.092 | Ref. | 0.005 | Ref. | 0.019 | Ref. |
| Sufficient (>=60min/day) | 0.540 | <0.001 | 0.389 | <0.001 | 0.197 | <0.001 | 0.009 | <0.001 | 0.073 | <0.001 |
| Missing | 0.530 | <0.001 | 0.407 | <0.001 | 0.193 | <0.001 | 0.010 | <0.001 | 0.083 | <0.001 |
| Caloric intake compared w/needs in active child of age/gender | ||||||||||
| Appropriate | 0.535 | Ref. | 0.390 | Ref. | 0.186 | Ref. | 0.010 | Ref. | 0.078 | Ref. |
| Excessive | 0.540 | 0.93 | 0.427 | 0.36 | 0.213 | 0.28 | 0.011 | 0.25 | 0.086 | 0.43 |
| Missing | 0.522 | 0.92 | 0.605 | 0.22 | 0.251 | 0.50 | 0.011 | 0.72 | 0.115 | 0.26 |
| Overweight status | ||||||||||
| Not overweight (<85th percentile) | 0.476 | Ref. | 0.391 | Ref. | 0.191 | Ref. | 0.010 | Ref. | 0.077 | Ref. |
| Overweight (≥85th percentile) | 0.653 | 0.002 | 0.421 | 0.35 | 0.197 | 0.76 | 0.010 | 0.46 | 0.087 | 0.24 |
| Obese status | ||||||||||
| Not obese (<95th percentile) | 0.505 | Ref. | 0.392 | Ref. | 0.192 | Ref. | 0.010 | Ref. | 0.077 | Ref. |
| Obese (≥95th percentile) | 0.695 | 0.001 | 0.451 | 0.30 | 0.198 | 0.83 | 0.011 | 0.53 | 0.099 | 0.11 |
| Pre-hypertension | ||||||||||
| <90th percentile | 0.530 | Ref. | 0.399 | Ref. | 0.191 | Ref. | 0.010 | Ref. | 0.080 | Ref. |
| ≥90th percentile | 0.651 | 0.038 | 0.465 | 0.62 | 0.234 | 0.33 | 0.009 | 0.73 | 0.087 | 0.82 |
Ref.; Reference
Derived using univariate regression of log molar concentration of urinary metabolites. Mean urinary phthalate metabolites represents retransformed mean from log base.