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Western blot analysis of proteinase-K resistant L-BSE PrP Sc in TgBoPrP mice before and after passage in sheep. The brain samples of TgBoPrP mice inoculated intracerebrally with either L-BSE/cattle or L-BSE/sheep were analyzed. PrPSc in the twice-passaged mice was detected with mAb T2. The numbers indicate three different mice.
