Table 2.
Comparision of laboratory tests and weight between the two groups before and after treatment
| Pretreatment | Post treatment | |||||
|---|---|---|---|---|---|---|
| Week 0 | Week 16 | |||||
| Parametes | Gliclazide | Vildagliptin | P | Gliclazide | Vildagliptin | P |
| Fasting TC (mg/dL) | 195.2 ± 26.9 | 190.1 ± 35.8 | 0.636 | 194.0 ± 32.2 | 192.6 ± 36.4 | 0.904 |
| Postprandial TC (mg/dL) | 193.1 ± 25.9 | 186.8 ± 34.8 | 0.544 | 191.3 ± 32.9 | 192.8 ± 37.2 | 0.899 |
| Fasting HDL (mg/dL) | 51.1 ± 10.0 | 60.0 ± 18.9 | 0.086 | 51.3 ± 10.4 | 62.3 ± 15.6 | 0.021 |
| Postprandial HDL (mg/dL) | 50.2 ± 9.3 | 59.3 ± 17.9 | 0.150 | 51.1 ± 10.8 | 62.9 ± 16.0 | 0.015 |
| Fasting Triglycerides (mg/dL) | 177.3 ± 87.3 | 197.1 ± 116.0 | 0.567 | 205.1 ± 100.3 | 190.7 ± 106.2 | 0.635 |
| Postprandial Triglycerides (mg/dL) | 207.9 ± 89.3 | 218,4 ± 110.0 | 0.849 | 221.8 ± 90.1 | 197.4 ± 86.1 | 0.342 |
| Fasting glucose (mg/dL) | 179 ± 57.9 | 168.7 ± 31.3 | 0.475 | 131.7 ± 30.5 | 132.9 ± 24.8 | 0.896 |
| Post prandial glucose (mg/dL) | 242.83 ± 71.7 | 241.4 ± 69.5 | 0.825 | 191.2 ± 54.8 | 194.5 ± 47.4 | 0.847 |
| A1c (%) | 9.2 ± 1.2 | 8.6 ± 0.9 | 0.109 | 6.9 ± 1.1 | 6.9 ± 0.8 | 0.800 |
| Weight | 82.0 ± 14.6 | 71.4 ± 8.0 | 0.012 | 83.4 ± 14.8 | 71.0 ± 8.1 | 0.005 |
| Weight Change (kg) | - | - | - | +1.4 ± 3.0 | −0.3 ± 2.0 | 0.048 |
Data are means ± SD. TC total cholesterol, HDL high dense lipoprotein