Fig. 5.
Summary of gene expression and somatic mutation differences between uterine serous (USC) and uterine endometrioid carcinomas (UEC) for the MYC pathway. Genes upregulated in USC were MYC (P = 3.3 × 10−8), TRRAP (P = 3.8 × 10−4), PI3KCA (P = 1.4 × 10−10), MAPK3 (P = 5.8 × 10−5), CAD (P = 6.9 × 10−9), ODC1 (P = 1.9 × 10−11), CKS1B (P = 9.2 × 10−14), SKP2 (P = 3.0 × 10−3), CDKN1A (P = 6.8 × 10−20), CCNE1 (P = 2.5 × 10−18), and CDK2 (P = 2.0 × 10−5). TP53 (P = 2.5 × 10−3) and FBXW7 (P = 3.8 × 10−4) were upregulated and somatically mutated. CDKN1A (P = 6.8 × 10−20) and TAF9 (5.9 × 10−13) were down in USC. This suggests upregulation of the MYC pathway in USC. A Wilcoxon rank test was used for RNA-Sequencing, and a Fisher’s Exact test for somatic mutations