Table 4.
Areas of activation emerging from the group subtraction
Location of peak activation | Brodmann’s area |
Cluster size |
t(20) | MNI coordinates |
||
---|---|---|---|---|---|---|
x | y | z | ||||
(Control > autism) | ||||||
LMFG | 9 | 133 | 4.30 | −50 | 12 | 36 |
RMFG | 10 | 21 | 3.54 | 42 | 42 | 0 |
LIFG | 47 | 74 | 4.09 | −24 | 8 | −14 |
RIFG | 47 | 66 | 3.63 | 42 | 28 | −6 |
MedFG | 8 | 128 | 3.94 | −6 | 20 | 48 |
Anterior cingulate | 33, 24 | 791 | 5.64 | 6 | 12 | 24 |
Cingulate gyrus | 32 | 57 | 3.58 | −4 | 26 | 34 |
LIPL | 40 | 42 | 3.85 | −42 | −38 | 26 |
LIPL | 40 | 18 | 3.50 | −58 | −38 | 22 |
RIPL | 40 | 33 | 3.97 | 42 | −28 | 24 |
R temporal pole | 22 | 20 | 3.30 | 52 | 10 | −4 |
R superior temporal gyrus | 22 | 140 | 4.22 | 46 | −26 | −6 |
R middle temporal gyrus | 39 | 76 | 5.07 | 44 | −66 | 20 |
L fusiform gyrus | 19 | 14 | 3.55 | −26 | −60 | −12 |
L parahippocampal gyrus | 28 | 12 | 3.88 | −22 | −20 | −20 |
L parahippocampal gyrus | 21 | 3.28 | −42 | −42 | −6 | |
L caudate | 63 | 3.79 | −18 | −14 | 26 | |
R caudate | 44 | 3.46 | 16 | −10 | 28 | |
R mammillary body | 27 | 3.57 | 4 | −14 | −12 | |
L thalamus | 57 | 3.64 | −2 | −22 | 8 | |
(Autism > control) | ||||||
R MFG | 8 | 44 | 3.56 | 34 | 28 | 44 |
R LPM area | 6 | 76 | 4.38 | 32 | −12 | 56 |
R superior parietal lobe | 7 | 18 | 3.81 | 28 | −70 | 48 |
Notes: L = left, R = right. The threshold for significant activation was P < 0.005 for a spatial extent of at least 10 voxels, uncorrected for multiple comparisons. Region labels apply to the entire extent of the cluster. The t-values and MNI coordinates are for the peak activated voxel in each cluster only.