Fig. 5.

Venous antithrombotic activity (A) and bleeding effect (B) of 5 in vivo. Antithrombotic activity was investigated in male Sprague–Dawley rats with the tissue thromboplastin-induced venous thrombosis model. The results are expressed as thrombus weight (mean ± SD, n = 8, **P < 0.01, ***P < 0.001 vs. control). (B) Different doses of compounds were infused into mice. Blood loss was determined by measuring the hemoglobin present in the water using a spectrophotometric method. The results were expressed as microliters of blood loss (mean ± SD, n = 6, *P < 0.05 vs. control).