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. 2015 Jun 22;112(27):8397–8402. doi: 10.1073/pnas.1509565112

Fig. 2.

Fig. 2.

Impaired urinary concentrating ability in Ksp-EP4−/− mice. (A) Twenty-four-hour urine volume and (B) osmolality (n = 9 for Ksp-Cre− mice, n = 16 for Ksp-EP4−/− mice) under basal conditions. **P < 0.01 vs. Ksp-Cre− mice. (C) Ksp-Cre− and Ksp-EP4−/− mice were injected i.p. with 0.4 μg/kg of dDAVP. Urine was collected after 2 h and urine osmolality was determined (n = 15). **P < 0.01 vs. Ksp-Cre− mice at 0 h; ##P < 0.01 vs. Ksp-EP4−/− mice at 0 h. (D) Serum AVP concentrations in the Ksp-Cre− and Ksp-EP4−/− mice. The results are presented as mean ± SEM.