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Function of PRUNE2/PCA3 in prostate cancer cells. (A) LNCaP cell proliferation in vitro after alteration of PCA3 and PRUNE2 levels or treatment with the androgen analog R1881. (B) Colony formation assay in soft agar medium of LNCaP cells transduced with ectopic PCA3 or PRUNE2, PCA3- or PRUNE2-shRNAs, or controls as indicated. In each experiment, mean ± SD is shown. *P < 0.05; **P < 0.01. (C) Cell cycle analysis by BrdU incorporation. (D) Cell-doubling time.
