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Epistatic interactions in the DGRP. Box plots illustrating nonsignificant additive effects of variants with significant (P < 5.0 × 10−12) additive by additive epistatic interactions. “Major” and “minor” denote major and minor alleles at each locus, respectively. (A) 2R_14845120_SNP (sano) and 3L_12009722_SNP (rols), (B) 3L_17718187_SNP (Ccn) and 3L_18823109_DEL (Indy), (C) 3R_21095783_SNP (CG11891) and 3R_3774964_INS (dsx), and (D) 3L_3891736_SNP (Fie) and 3R_10263276_SNP (cv-c).
