(A) Representative PCR of Ppar, App695, and Psen1 transgene DNA expression in the hippocampus of 4-mo-old WT, Pparα−/−, 5XFAD (5X), and 5X/α−/− mice. (B and C) Average wet brain weight (B) and gross body weight (C) for WT, Pparα−/−, 5X, and 5X/α−/− mice. For wet brain weight, the olfactory lobes and brainstem were removed. ●, internal positive control.