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Schematic representation of the mechanism underlying MP internalization in neutrophils. Platelet MPs express 12-LO, and generate 12(S)-HETE on membrane phospholipid hydrolysis by sPLA2-IIA. 12(S)-HETE triggers MP internalization in neutrophils through BLT2 activation, thereby promoting platelet MP cargo transfer to neutrophils. The concerted actions of sPLA2-IIA and 12-LO enhance inflammation.
