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. 2015 Jun 22;112(27):8260–8265. doi: 10.1073/pnas.1505405112

Fig. 3.

Fig. 3.

In vitro glucose-responsive release of insulin from GRVs. (A) In vitro accumulated insulin release from the GRVs in several glucose concentrations at 37 °C. *P < 0.05 for GRVs in 400 mg/dL glucose solution compared with GRVs in 100 or 0 mg/dL glucose solution. (B) Self-regulated profiles of the GRVs and GRVs containing one-half the amount of GOx present the rate of insulin release as a function of glucose concentration. *P < 0.05 for GRV(E + I) compared with GRV(1/2E + I). (C) Pulsatile release profile of GRVs presents the rate of insulin release as a function of glucose concentration (100 mg/dL and 400 mg/dL). (D) CD spectra of native insulin solution and insulin released from the GRVs incubated with 400 mg/dL glucose. Deg, degree. Error bars indicate SD (n = 3).