Fig. 1.

C20-D₃-vitamin administration reduces lipofuscin-related fundus AF. Representative fundus AF images taken with 488-nm (A) or 790-nm (C) excitation from 9-mo-old wild-type (WT) and Abca4^−/− mice. Animals were fed with either a standard diet (control) or a diet in which vitamin A was replaced by C20-D₃-vitamin A from weaning (treated). The bar charts illustrate average fundus AF intensities at 488 nm (B) and 790 nm (D), with SDs for each cohort of animals (n = 10 eyes of 10 animals). Unless noted with a bar, asterisks represent significant deviations (P < 0.05) from WT control animals fed a standard diet.