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Median profiles (continuous lines), 95% prediction intervals (broken lines) and observed data (filled circles) for plasma 6-MP and intracellular RBC 6-TGN and 6-MMPR following oral dosing of 6-MP (75 mg m–2 daily) in ALL children for 34 weeks (6-MP and 6-MMPR predictions and data during the dosing interval only has been included) 43
