Table 1.

Organ/tissue volumes (V) and plasma flows (Q) for adults and children and tissue/plasma partition ratios (K_p) for 6-MP used in the PBPK model

Parameters*	Age(years)	Organs/Tissues
		Plasma†	Muscle	Kidney	Liver	Gut	Enterocyte	Skin	Bone marrow	Spleen	Thymus	Rest of body
V (l)*	0	0.1	0.8	0.03	0.1	0.2	0.01	0.2	0.05	0.01	0.01	– ‡
	1	0.3	1.9	0.07	0.3	0.3	0.02	0.4	0.15	0.03	0.03	–
	5	0.9	5.6	0.1	0.6	0.6	0.04	0.57	0.34	0.05	0.03	–
	10	1.5	11	0.2	0.8	0.9	0.07	0.8	0.6	0.08	0.04	–
	15	2.6	24	0.3	1.3	1.3	0.1	2	1.1	0.1	0.03	–
	18	2.9	29	0.3	1.8	1.7	0.1	3.3	1.2	0.2	0.03	–
Q (l h–1)	0	15.2	0.9	3.2	1.1	2.4	0.9	0.9	0.5	0.5	0.2	– §
	1	41.1	2.1	6.7	2.3	4.9	2.5	1.7	1.2	1.1	0.6	–
	5	90.7	7.1	19.3	7.4	15.9	5.5	5.7	2.7	3.4	1.36	–
	10	164.9	15.9	31.6	12.0	25.9	9.9	9.2	5.0	5.5	2.5	–
	15	196	32.7	43.3	14	30	11.8	10.8	5.9	6.4	2.9	–
	18	196	36.5	43.7	14	30	11.8	10.7	5.9	6.4	2.9	–
Kp		–	0.8	0.83	0.82	0.85	–	0.78	0.64	0.84	0.84	0.2

^*References 25,26.

^†Cardiac output for flows.

^‡BW − ∑V_T.

^§CO − ∑Q_T.