Table 1.

Pharmacokinetic and pharmacodynamic variables of prasugrel active and inactive metabolites in seven healthy volunteers, who ingested 200 ml of grapefruit juice or water three times a day for 4 days, and a single 10 mg dose of prasugrel on day 3 with an additional 200 ml of grapefruit juice or water

The C_max, t_½ and AUC data are given both as geometric means (GeoCV) and as arithmetic means ± SD, t_max as median (range), and average and maximal inhibition as arithmetic means ± SD. The geometric mean ratios (C_max, t_½ and AUC) and mean differences (average and maximal inhibition) between the phases are given with 95% confidence intervals. Abbreviations are as follows: AUC_0–∞, area under the plasma concentration–time curve from time 0 to infinity; C_max, peak plasma concentration; GeoCV, geometric coefficient of variation; t_max, time to C_max; t_½, elimination half-life.