Figure 7.

The BDP-induced activation of p38 MAPK is mediated through focal adhesion kinase (FAK)

Western blots showing the effects of pre-treating fast-twitch (F) and slow-twitch (S) muscle fibre bundles with 10 μm FAK inhibitor (FAKi) 14, for 10 min, on the phosphorylation of p38 MAPK (A), JNK (B) and ERK1&2 (C). The muscle fibre bundles were then treated with the Ringer solution containing BDP alone or BDP plus the inhibitor as shown below each Western blot for a further 10 min. Note that pre-treating the fibre bundles with FAKi 14 abolishes the BDP-induced increase in the phosphorylation of p38 MAPK (A) and ERK1&2 (C) but not that of JNK (B).