Figure 4.

Daily heat stress treatment normalized continuously activated mitophagy induction

Open columns, non-heat stress; filled columns, heat stress. Two- or three-way ANOVA was performed. ^#P < 0.05, main effect of denervation. *P < 0.05, main effect of heat stress. ^†P < 0.05 vs. non-heat stress/sham. (^†)P = 0.05 vs. non-heat stress/sham. ^§P < 0.05 vs. heat stress/denervation/colchicine. Abbreviation: USP, ubiquitin-specific-processing protease; SQSTM1, sequestosome 1; LC3, microtubule-associated protein 1A/1B-light chain 3; Mfn2, mitofusin-2; Opa1, Optic atrophy 1; Fis1, mitochondrial fission 1; Drp1, dynamin-related protein 1; n.s. not significant.