Figure 2.

Ginsenoside CK acts rapidly to potentiate P2X7 receptor responses and is prevented by selective antagonists. (A) CK can potentiate P2X7 receptor responses in buffer containing physiological concentrations of CaCl₂ and MgCl₂. Data are collated from 5 to 9 individual wells. **P < 0.05, significantly different as indicated; one-way anova with Dunnett's post-test. (B) Dye uptake plot showing co-injection of 100 μM ATP plus 10 μM CK compared with 100 μM ATP alone. The mean ± SEM response from three individual wells is shown. (C) Mean data from 7 to 8 wells measuring ATP-induced dye uptake. Selective antagonists AZ10606120 and A-438079 inhibited the response. **P < 0.05, significantly different to ATP control; one-way anova.