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CK acts as a positive allosteric modulator of P2X7 receptors. (A) A concentration-response curve for the potentiating effect of CK. PPD is included as a control. (B) Concentration-response curves were generated for ATP (10 μM – 1 mM), with or without 10 μM CK. Data are the means, with SEM, of five independent experiments. (C) Concentration-response curves were generated for BzATP (1 μM – 0.3 mM), with or without 10 μM CK. Sigmoidal dose responses were fitted in GraphPad Prism.
