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. 2015 Apr 29;172(13):3341–3352. doi: 10.1111/bph.13122

Figure 2.

Figure 2

ALDH2 inhibition attenuates nitrite-induced vasorelaxation in rat aortae. Concentration–response curves to sodium nitrite in the presence or absence of ALDH2 inhibitor, cyanamide, during (A) normoxia (n ≥ 5), (B) hypoxia (n ≥ 5), and ALDH2 substrate, propionaldehyde, during (C) normoxia (n ≥ 5) and (D) hypoxia (n ≥ 5). Relaxation is expressed as mean ± SEM percentage reversal of PE-induced tone. *P < 0.05, **P < 0.01 and ***P < 0.001 control versus cyanamide or propionaldehyde by two-way anova.