Figure 4.

Tolerance-independent inactivation of ALDH2 attenuates vasorelaxation in rat aortae. (A) Concentration–response curve to NaNO₂ in the presence or absence of GTN during hypoxic conditions. Relaxation is expressed as mean ± SEM percentage reversal of PE-induced tone (n = 10); *P < 0.05, ***P < 0.001 versus control, two-way anova. (B) The effect of sodium nitrite (control), in the presence or absence of GTN during hypoxic conditions, on mitochondrial ALDH2 activity (mean ± SEM from n = 4–6 animals; *P < 0.05 vs. control by one-way anova).