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. 2015 Apr 29;172(13):3341–3352. doi: 10.1111/bph.13122

Figure 5.

Figure 5

GTN infusion attenuates nitrite-induced vasorelaxation in the resistance vasculature of HF patients. Forearm vasodilator measurements following nitrite infusion in HF patients subjected to 4 h infusion of (A) saline (n = 8 patients) or (B) GTN (n = 11 patients) treatment. *P < 0.05, **P < 0.01, ***P < 0.001 compared with baseline. (C) Comparison of pre- and post-GTN infusion following 7.84 μmol·min−1 sodium nitrite during hypoxic conditions (n = 8 and n = 11 patients, respectively; P = 0.08). (D) Concentration–response curve to GTN in isolated resistance vessels from HF patients (saline n = 7; GTN n = 11 patients).