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. 2015 Apr 24;172(13):3383–3396. doi: 10.1111/bph.13130

Figure 2.

Figure 2

Tollip increases MI-induced mortality, infarct size and cardiac dysfunction. (A) Kaplan–Meier survival curves for Tollip+/+ and Tollip KO mice after MI (*P < 0.05 vs. Tollip+/+/MI group). (B) Representative images of haematoxylin and eosin staining in heart cross-sections of Tollip+/+ and Tollip−/− mice at 3 days and 4 weeks after MI surgery (n = 6 mice per experimental group). (C) Measurement of infarct size in the heart tissue of mice from Tollip+/+ and Tollip−/− groups. *P < 0.05 versus Tollip+/+/MI group at 3 days; #P < 0.05 versus Tollip+/+/MI group at 4 weeks. (D) Echocardiographic and haemodynamic assessment of cardiac function in Tollip+/+ and Tollip−/− mice after MI (n = 8 mice per experimental group). *P < 0.05 versus Tollip+/+/sham operated group; #P < 0.05 versus Tollip+/+/MI group. (E) Comparison of mortality between NTG mice and Tollip-TG mice at 3 days and 4 weeks post-MI injury (*P < 0.05 vs. NTG/MI group). (F,G) Representative images and evaluation of infarct size in NTG and Tollip-TG mice at 3 days and 4 weeks after MI surgery (n = 6 mice per experimental group). *P < 0.05 versus NTG/MI group at 3 days; #P < 0.05 versus NTG/MI group at 4 weeks. (H) The parameters of cardiac function in NTG and Tollip-TG mice after 4 weeks of MI surgery (n = 8 for each group). *P < 0.05 versus NTG/sham operated group; #P < 0.05 versus NTG/MI group.