Table 10. Summary of the impact of different software settings on LCI of N₂MBW.

LCI change	Statistical significance	Clinical relevance	Max. No. of children with>10% change
Environmental conditions	Yes	No	2 (7%)
Apparatus dead space	Yes	No	0
Signal processing and detection limits	Only for algorithms concerning O2 and CO2 signal processing	Yes, for those mentioned	11 (37%)
Signal delay times	Yes, for O2 delay changes of ±40 ms upwards	Yes	18 (60%)

Overview of impact on LCI after change of software settings. High quality N₂MBW tests of 30 children with different lung disease were reanalyzed with changed software settings. Several parameters were changed according to four sectors, environmental conditions (e.g. ambient temperature), setup parameter (apparatus dead space), software algorithm (e.g. O₂ response-time correction), and flow-gas signal delay times. Because of the uniformity of change statistical significance might be reached over the study population without clinical relevance (defined as >10% change of baseline LCI for the individual measurement; and for the change in software setting if >10% of all children showed such a LCI change >10%).