Scheme 1. Synthesis of Compounds 3, 7, and 10.
Reagents and conditions: (a) KHMDS, 1,4-dioxane, 0 °C to rt, 15 min, then 80 °C, 22 h, and HCl acidification; (b) Cs2CO3, DMF, 50 °C, 1.5 h; (c) Cs2CO3, DMF, 75 °C, 0.5 h.
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