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. 2015 Mar 11;58(13):5164–5185. doi: 10.1021/jm5016846

Figure 4.

Figure 4

Nitroheterocycles: (A) analogs of nitazoxanide 1416;83,84 (B) furanyl thiazoles 1720 and phenylthiazoles 21 and 22 (inactive against C. difficile, MIC > 100 μg/mL);8587 (C) thiazolides with a nitrothiazole ring, similar to nitazoxanide;88 (D) nitrofuranylsemicarbazone 28;89 (E) the six 5-nitroimidazole scaffolds 2934 in the library of metronidazole triazole conjugates (crude, >85% purity);90 (F) quinoxalines 3536.92