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. 2015 Mar 11;58(13):5164–5185. doi: 10.1021/jm5016846

Table 2. Pexiganan and Cecropin-Melittin Hybrid Peptidesa with Antimicrobial Activity against C. difficile.

peptide amino acid sequenceb
pexiganan, 108 GIGKFLKKAKKFGKAFVKILKK-NH2
CAMEL0, 109 KWKLFKKIGAVLKVL
CAMEL9, 110 KWRLFKNIGAVLKVL
CAMEL24, 111 KWKLFKHIGAVLKVL
CAMEL42, 112 HWKLFKKIGAVLKVL
CAMEL46, 113 KWKLFKGIRAVLKVL
CAMEL48, 114 KWKLGKKILAVLKVL
CAMEL48D, 115 KWKLGKKILAVLKVL
CAMEL101, 116 KWKLGKKILRVLKVL
CAMEL102, 117 GWKLGKKILRVLKVL
CAMEL108, 118 KWKLGKKILNVLKVL
CAMEL109, 119 GWRLGKKILRVLKVL
CAMEL110, 120 GWKLGKKILNVLKVL
CAMEL123, 121 LWKLFKKIRRVLRVL
CAMEL129, 122 LWKLFKKINRVLKVL
CAMEL135, 123 GWRLIKKILRVFKGL
CAMEL136, 124 VWRLIKKILRVFKGL
a

Adapted from Table 1 from OH et al.116

b

Bold italicized letters in cecropin–melittin hybrid peptides indicate sites of mutation compared with the CAMEL0 sequence.