Table 4.
Comparison of Clinical variations between SCD patients with and without mutations in hOGG1326 Ser>Cys gene and XRCC1 280 Arg>His gene.
| Symptoms | hOGG1 mutant ( n = 190 ) | hOGG1 wild ( n = 60 ) | P value# | XRCC1 280 Mutant ( n = 192 ) | XRCC1 wild ( n = 58 ) | P value# |
|---|---|---|---|---|---|---|
|
| ||||||
| Chest pain | 170 (89.4) | 50 (83.3) | 0.253 | 140 (72.9) | 35 (60.3) | 0.073 |
|
| ||||||
| Bone joint pain | 130 (68.4) | 40 (66.6) | 0.874 | 120 (62.5) | 35 (60.3) | 0.76 |
|
| ||||||
| Abdominal pain | 165 (86.8) | 56 (93.3) | 0.246 | 105 (54.6) | 28 (48.2) | 0.453 |
|
| ||||||
| Fatigue | 95 (50) | 25 (41.6) | 0.3 | 100 (52.1) | 31 (53.4) | 0.881 |
|
| ||||||
| Fever (no. of times/yr) | ||||||
| 0 – 5 times | 35 (18.4) | 8 (13.3) | 0.435 | 27 (14.1) | 3 (5.2) | 0.103 |
| 6 – 12 | 20 (10.5) | 5 (8.3) | 0.806 | 18 (9.3) | 9 (15.5) | 0.226 |
| > 12 | 11 (5.7) | 3 (5.0) | 1.0 | 8 (4.1) | 5 (8.6) | 0.186 |
|
| ||||||
| Splenomegaly | ||||||
| 0 – 2cm | 65 (34.2) | 27 (45.0) | 0.166 | 77 (40.1) | 30 (51.7) | 0.131 |
| 2 – 4 cm | 37 (19.4) | 15 (25.0) | 0.365 | 45 (23.4) | 20 (34.4) | 0.123 |
| > 6 cm | 24 (12.6) | 10 (16.6) | 0.516 | 18 (9.4) | 4 (6.9) | 0.791 |
|
| ||||||
| Blood transfusion frequency(no./yr) | ||||||
| 0 – 3 | 42 (22.1) | 20 (33.3) | 0.08 | 50 (26.0) | 20 (34.4) | 0.24 |
| 4 – 6 | 28 (14.7) | 11 (18.3) | 0.54 | 25 (13.0) | 10 (17.2) | 0.39 |
| 7 – 10 | 10 (5.2) | 6 (10.0) | 0.22 | 10 (5.2) | 5 (8.6) | 0.34 |
|
| ||||||
| Age of onset of disease | ||||||
| 0 – 3 yr | 15 (7.8) | 8 (13.3) | 0.2 | 10 (5.2) | 4 (6.9) | 0.74 |
| 3 – 6 yr | 27 (14.2) | 14 (23.3) | 0.11 | 12 (6.2) | 4 (6.9) | 0.76 |
| 6 – 9 yr | 31 (16.3) | 16 (26.6) | 0.08 | 40 (20.8) | 18 (31.0) | 0.11 |
| > 9 yr | 48 (25.2) | 22 (36.6) | 0.09 | 60 (31.2) | 25 (43.1) | 0.11 |
#
by Fisher’s exact test two tailed, sample frequency expressed as no.(%)