Gray Matter overgrowth in Autism. The bars represent abnormalities in Different Cerebral Regions (standard deviations from normal average) in Children and Adolescents with ASD. Note the general gradient of abnormality with frontal and temporal regions most abnormally enlarged. References: 1, Carper et al., 2002 3.4 years; 2, Bloss and Courchesne, 2007 3.8 years; 3, Kates et al., 2004 (7.6 years); 4, Palmen et al., 2005 11.1 years; 5, Hazlett et al., 2005 19.1; 6. Schumann et al,. 2010 2–4 years. (From Courchesne et al, 2007)