Table 2.
Univariate and multivariate logistic regression of baseline and day 3 sTM levels associated with clinical outcomes
| Day 0 thrombomodulin | Day 3 thrombomodulin | |||||||
|---|---|---|---|---|---|---|---|---|
| Odds ratio | 95 % confidence interval | P value | Odds ratio | 95 % confidence interval | P value | |||
| Univariate analysis | ||||||||
| Plasma thrombomodulin levels | 3.74 | 2.53 | 5.52 | < 0.001 | 3.82 | 2.53 | 5.78 | < 0.001 |
| Multivariate analysis | ||||||||
| Plasma thrombomodulin levels | 2.40 | 1.52 | 3.83 | < 0.001 | 2.80 | 1.69 | 4.66 | < 0.001 |
| Age (years) | 1.03 | 1.01 | 1.05 | < 0.001 | 1.03 | 1.01 | 1.05 | < 0.003 |
| Gender (male) | 1.00 | 0.59 | 1.67 | 1 | 1.23 | 0.65 | 2.07 | 0.5 |
| Ethnicity (caucasian) | 1.11 | 0.95 | 1.29 | 0.2 | 1.2 | 1.02 | 1.4 | < 0.03 |
| APACHE III | 1.03 | 1.02 | 1.04 | < 0.001 | 1.02 | 1.01 | 1.04 | < 0.001 |
| Baseline creatinine | 0.84 | 0.58 | 1.22 | 0.4 | 0.83 | 0.99 | 1.03 | 0.4 |
| Allocation to fluid liberal arm | 0.97 | 0.58 | 1.61 | 0.9 | 0.84 | 0.48 | 1.47 | 0.5 |
| Sepsis | 1.31 | 0.73 | 2.36 | 0.4 | 1.23 | 0.63 | 2.29 | 0.5 |