Table 1. Gene list with protein name, chromosomal location, and ANOVA comparing mean expression levels between Aging and Development.
| Gene Name | Protein Name | Chromosome | Probe | Fold change | p-value |
|---|---|---|---|---|---|
| CYTH3 | General receptor for phosphoinositides | 7p22.1 | 1 | -1.16 | 0.0001 |
| IMPA1 | Inositol monophosphatase 1 | 8q21.1-q21.3 | 1 | 1.21 | 3.27E-07 |
| INPP5A | Type I inositol 1,4,5-trisphosphate 5-phosphatase | 10q26.3 | 1 | 1.23 | 9.44E-07 |
| IP6K1 | Inositol hexakisphosphate kinase 1 | 3p21.31 | 1 | 1.2 | 5.19E-07 |
| ITPKB | Inositol-trisphosphate 3-kinase B | 1q42.12 | 2 | 1.62 | 2.16E-13 |
| MTM1 | Myotubularin | Xq27.3-q28 | 2 | 1.26 | 1.21E-06 |
| MTMR14 | Myotubularin-related protein 14 | 3p26 | 2 | 1.14 | 1.31E-08 |
| PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4 | 3q22.1 | 1 | 1.27 | 8.08E-10 |
| PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma | 19p13.3 | 2 | -1.22 | 4.64E-07 |
| PRKCD | Protein kinase C, delta | 3p21.31 | 1 | -1.27 | 2.99E-06 |
| SACM1L | Phosphatidylinositide phosphatase SAC1 | 3p21.3 | 1 | 1.27 | 1.16E-11 |
| SLC2A13 | Solute carrier family 2 (facilitated glucose transporter), member 13 (HMIT) | 12q12 | 1 | -1.67 | 1.29E-09 |
| SYNJ1 | Synaptojanin-1 | 21q22.2 | 2 | 1.32 | 9.25E-06 |
| SYNJ2 | Synaptojanin-2 | 6q25.3 | 1 | 1.81 | 1.85E-15 |
| TMEM55B | Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase | 14q11.1 | 1 | 1.2 | 9.55E-13 |
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 10p12.2 | 2 | 1.27 | 0.0005 |
| PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase | 10q23 | 1 | -1.27 | 0.0004 |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | 19p13.11 | 1 | -1.12 | 0.0005 |
| PRKCA | Protein kinase C, alpha | 17q22-q24 | 2 | 1.14 | 0.0006 |
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 5q13.1 | 2 | 1.16 | 0.00071 |
| ISYNA1 | Inositol-3-phosphate synthase 1 | 19p13.11 | 1 | ns | |
| MINPP1 | Multiple inositol polyphosphate phosphatase 1 | 10q23 | 2 | ns | |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 | 1q25.2-q25.3 | 4 | ns | |
| CDIPT | CDP-diacylglycerol—inositol 3-phosphatidyltransferase | 16p11.2 | 2 | ns | |
| GRASP | General receptor for phosphoinositides associated scaffold protein | 12q13.13 | 1 | ns | |
| PI4KB | Phosphatidylinositol 4-kinase beta | 1q21 | 2 | ns | |
| INPP1 | Inositol polyphosphate 1-phosphatase | 2q32 | 1 | ns | |
| PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3 | 18q12.3 | 1 | ns | |
| IPMK | Inositol polyphosphate multikinase | 10q21.1 | 1 | ns | |
| INPP4A | Type I inositol 3,4-bisphosphate 4-phosphatase | 2q11.2 | 2 | ns | |
| PIK3C2B | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta | 1q32 | 1 | ns | |
| DAGLA | Diacylglycerol lipase, alpha | 11q12.3 | 1 | ns | |
| AKT1 | Protein kinase B | 14q32.32-q32.33 | 2 | ns | |
| PI4K2A | Phosphatidylinositol 4-kinase type 2-alpha | 10q24 | 1 | ns | |
| PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | 1p34.1 | 2 | ns | |
| OCRL | Inositol polyphosphate 5-phosphatase OCRL-1 | Xq25 | 2 | ns | |
| INPPL1 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | 11q23 | 2 | ns | |
| PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 3q22.3 | 1 | ns | |
| PIP5K1A | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha | 1q21.3 | 3 | ns | |
| SLC5A3 | Solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 (SMIT) | 21q22.11 | 4 | ns | |
| PLA2G4A | Phospholipase A2, group IVA (cytosolic, calcium-dependent) | 1q25 | 1 | ns | |
| PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 3q26.3 | 1 | ns | |
| PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | 20p12 | 2 | ns | |
| DGKE | diacylglycerol kinase, epsilon | 17q22 | 2 | ns | |
| IPPK | Inositol-pentakisphosphate 2-kinase | 9q22.31 | 1 | ns | |
| PLCD1 | 1-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | 3p22-p21.3 | 1 | ns | |
| ITPK1 | Inositol-tetrakisphosphate 1-kinase | 14q32.12 | 4 | ns | |
| IMPA2 | Inositol monophosphatase 2 | 18p11.2 | 1 | ns | |
| PIK3C2A | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha | 11p15.5-p14 | 1 | ns |
The probe column indicates type of probe used: 1, only one probe in database; 2, highest intensity probe covering all transcripts; 3, probe used covers all transcripts but is not highest intensity probe; 4, highest intensity probe as none of the probes covered all transcripts. The ANOVA column shows whether levels in Aging are higher or lower than in Development, after correcting for 49 comparisons (p < 0.001). ns, not significant.