Table 1. Plasma and tissue concentrations of pitavastatin after intravenous administration of pitavastatin-NP or pitavastatin at time of reperfusion.

Pitavastatin-NP containing 1.0 mg/kg pitavastatin
Groups	Time after intravenous administration
	30 minutes	3 hours	24 hours
Ischemic myocardial area at risk	236 ± 32 #	48 ± 8 #	6 ± 1#
Non-ischemic myocardium	134 ± 17	17 ± 4	3 ± 1
Lung	194 ± 31	28 ± 3	2 ± 1
Plasma	302 ± 28*	86 ± 17	4 ± 1
1.0 mg/kg pitavastatin
Groups	Time after intravenous administration
	30 minutes	3 hours	24 hours
Ischemic myocardial area at risk	256 ± 79	22 ± 3	31 ± 23
Non-ischemic myocardium	260 ± 79	11 ± 2	35 ± 25
Lung	184 ± 29	55 ± 32	9 ± 8
Plasma	214 ± 11	60 ± 8	6 ± 2

Data are expressed as the mean±SEM (ng/g•tissue for myocardial or lung tissue, and ng/mL for plasma, n = 6 each).

*P<0.05 versus pitavastatin group.

#P<0.05. versus non-ischemic myocardium by the unpaired t-test.

Values below measurable limits are replaced with the one-half value of the limits. The statistical analysis of differences between two groups, in which one of values was replaced by the complementary value, was assessed with the unpaired t-test after transforming values into a natural logarithm.