Fig 4. Irreversible and bistable switch in LMPPs commitment into B-lymphoid LRPs (pro-B cells).

Steady state concentrations of FLT3, ZNF521, PAX5 and CD19 as functions of an external signal T _EBF1, which promotes B-cell development and represses ZNF521. All the points located on the negative semiaxis, the shaded area, are inaccessible (expression levels of some species assume negative values). LP, Limit Point.