Fig 5. Comparison between experimental expression profiling and computed attractors.

Each condition, for both experimental and model results, is normalized with respect to the given maximum value. It is possible to note a good agreement, in terms of bistable behavior, between the model prediction, the measured expression of the key factors involved in the commitment switch and the markers of the multipotent and the committed stage (FLT3 and CD19), respectively. Blue bars correspond to the LMPP stage, green bars to the LRP in the pro-B phase.