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. 2015 Jul 13;10(7):e0132208. doi: 10.1371/journal.pone.0132208

Fig 6. EBF1-dependence of the B-cell development bifurcation diagram w.r.t the ZNF521 transcriptional activation.

Fig 6

(a) EBF1 versus external factor T EBF1 with no activation of ZNF521, T ZNF521 = 0. Overexpression of EBF1 is sufficient to switch the system from the LMPP state (low EBF1) to the pro-B (high EBF1) state, as indicated by the arrows. (b) EBF1 versus external factor T EBF1 with transcriptional activation of ZNF521, T ZNF521 = 0.12. A couple of limit points (LPs) defines a region of bistability for the proposed network. In this case, transcriptional activation of ZNF521 may convert the system from an irreversible to a reversible bistable switch. (c) EBF1 versus external factor T EBF1 with transcriptional activation of ZNF521, T ZNF521 = 0.3. Consistently, higher values of transcriptional activation of ZNF521 entailing a sharp delay in B-cell development, showing a more ultrasensitive response to higher values of T EBF1.