Table 2.
Microarray analysis of focal adhesion–related gene expression regulation upon FH535 treatment
| Gene | ID | Normalized intensity
|
|
|---|---|---|---|
| Control | FH535 | ||
| RPSA | 3921 | 16.551584 | 16.069508 |
| RHOA | 387 | 15.761177 | 14.786651 |
| ACTN4 | 81 | 15.032014 | 14.01403 |
| CAPN2 | 824 | 14.947017 | 15.841314 |
| RAC1 | 5879 | 14.251518 | 15.113209 |
| FLNA | 2316 | 14.083586 | 13.488903 |
| FLNB | 2317 | 13.958575 | 13.296808 |
| ITGB5 | 3693 | 13.888797 | 13.484464 |
| DNM1 | 1759 | 13.640091 | 12.518821 |
| TMEM132A | 54972 | 13.622586 | 13.150153 |
| RAP1A | 5906 | 13.5597315 | 14.039375 |
| HGS | 9146 | 13.533683 | 13.846248 |
| VCL | 7414 | 13.376745 | 13.681126 |
| DIAPH1 | 1729 | 13.16062 | 13.659487 |
| GNG11 | 2791 | 13.022779 | 13.403848 |
| AKT1 | 207 | 12.957863 | 12.259176 |
| RAC2 | 5880 | 12.955015 | 11.604415 |
| ITGA3 | 3675 | 12.797894 | 12.391577 |
| ITGB1 | 3688 | 12.738785 | 13.636554 |
| CAV1 | 857 | 12.61244 | 13.617725 |
| ITGB2 | 3689 | 12.546266 | 11.473748 |
| ACTN1 | 87 | 12.409878 | 11.967234 |
| ITGAV | 3685 | 12.278682 | 14.3424 |
| ITGA6 | 3655 | 12.273888 | 14.392418 |
| ITGA5 | 3678 | 12.169847 | 10.866323 |
| ILK | 3611 | 12.11682 | 11.583433 |
| TLN1 | 7094 | 12.096641 | 10.645829 |
| SGCE | 8910 | 12.047686 | 12.282321 |
| ITGB4 | 3691 | 11.982763 | 11.56935 |
| PRKCA | 5578 | 11.918201 | 13.803304 |
| CTNNB1 | 1499 | 11.900537 | 11.841962 |
| FXYD5 | 53827 | 11.859393 | 10.980669 |
| AKT2 | 208 | 11.791592 | 10.995004 |
| CAV2 | 858 | 11.534644 | 11.731664 |
| VAV2 | 7410 | 11.322939 | 10.17948 |
| CDC42 | 998 | 11.250544 | 11.791042 |
| PARVB | 29780 | 11.224628 | 9.830263 |
| ZYX | 7791 | 10.997072 | 9.663998 |
| VASP | 7408 | 10.877319 | 10.418066 |
| RAF1 | 5894 | 10.594473 | 10.865986 |
| SHC1 | 6464 | 10.287678 | 8.595637 |
| DSP | 1832 | 10.226259 | 11.500326 |
| PARVA | 55742 | 10.0804615 | 10.301352 |
| ITGAM | 3684 | 10.003317 | 8.889115 |
| AKT3 | 10000 | 9.999831 | 12.071189 |
| HRAS | 3265 | 9.972342 | 9.272375 |
| PDPK1 | 5170 | 9.005413 | 9.698432 |
| HPSE | 10855 | 8.978405 | 8.067395 |
| PTK2 | 5747 | 8.939062 | 10.820772 |
| DNM2 | 1785 | 8.613899 | 7.43392 |
| SH3PXD2A | 9644 | 8.566784 | 9.949804 |
| BCAR1 | 9564 | 8.529809 | 7.7692404 |
| ACTN2 | 88 | 8.437073 | 7.474538 |
| PARD6B | 84612 | 8.172608 | 9.636746 |
| SOS1 | 6654 | 7.9648976 | 7.5355105 |
| DST | 667 | 7.7908773 | 11.245214 |
| ITGA11 | 22801 | 7.7725782 | 7.250522 |
| ITGA9 | 3680 | 7.725706 | 7.2797456 |
| PIK3CA | 5290 | 7.546133 | 9.475706 |
| CRK | 1398 | 7.5114365 | 8.404298 |
| ITGA2B | 3674 | 7.474538 | 6.8249826 |
| PXN | 5829 | 7.426979 | 6.493304 |
| SPTB | 6710 | 7.143782 | 6.598218 |
| PTEN | 5728 | 7.0376005 | 9.120998 |
| CASK | 8573 | 6.554297 | 9.147331 |
| ITGA2 | 3673 | 6.538141 | 10.171594 |
| SORBS1 | 10580 | 6.5160394 | 7.080136 |
| SELE | 6401 | 5.8820415 | 7.629673 |
| ARHGAP5 | 394 | 5.628543 | 7.9602804 |
| ITGA1 | 3672 | 5.3547735 | 7.6031985 |
| ZEB2 | 9839 | 5.2203803 | 6.942315 |