Table 3.
Microarray analysis of adhesion junction–related gene expression regulation upon FH535 treatment
| Gene | ID | Normalized intensity
|
|
|---|---|---|---|
| Control | FH535 | ||
| PFN1 | 5216 | 16.843973 | 16.144138 |
| RHOA | 387 | 15.761177 | 14.786651 |
| ACTN4 | 81 | 15.032014 | 14.01403 |
| CD44 | 960 | 15.006962 | 16.199093 |
| RAC1 | 5879 | 14.251518 | 15.113209 |
| CTNNA1 | 1495 | 14.209974 | 14.654735 |
| FLNA | 2316 | 14.083586 | 13.488903 |
| MAPRE1 | 22919 | 13.413141 | 13.8757925 |
| DIAPH1 | 1729 | 13.16062 | 13.659487 |
| RAC2 | 5880 | 12.955015 | 11.604415 |
| CD99 | 4267 | 12.8705635 | 12.11682 |
| JUP | 3728 | 12.776809 | 12.098349 |
| ACTN1 | 87 | 12.409878 | 11.967234 |
| CDH2 | 1000 | 12.27524 | 13.657263 |
| TLN1 | 7094 | 12.096641 | 10.645829 |
| IQGAP1 | 8826 | 11.903805 | 15.008826 |
| CTNNB1 | 1499 | 11.900537 | 11.841962 |
| PKP3 | 11187 | 11.572304 | 11.483009 |
| CAV2 | 858 | 11.534644 | 11.731664 |
| MGAT5 | 4249 | 11.399225 | 12.44798 |
| CSNK2A1 | 1457 | 11.389523 | 10.994029 |
| PLEK2 | 26499 | 11.380254 | 12.049034 |
| ANAPC1 | 64682 | 11.330902 | 11.025982 |
| NOTCH1 | 4851 | 11.311136 | 10.345143 |
| CDC42 | 998 | 11.250544 | 11.791042 |
| NOTCH2 | 4853 | 11.125797 | 10.202223 |
| WASL | 8976 | 10.930079 | 12.483249 |
| DLG5 | 9231 | 10.567565 | 11.019769 |
| SRC | 6714 | 10.48147 | 9.648777 |
| PAK4 | 10298 | 10.446864 | 8.676079 |
| VEGFA | 7422 | 10.250756 | 7.901348 |
| ZEB1 | 6935 | 10.177025 | 13.283847 |
| JAM3 | 83700 | 10.084784 | 9.556893 |
| PVRL2 | 5819 | 10.018614 | 8.147698 |
| MET | 4233 | 9.986441 | 12.74971 |
| CSNK2A2 | 1459 | 9.960693 | 9.169151 |
| PTPN1 | 5770 | 9.82763 | 9.271097 |
| PTK2B | 2185 | 9.636893 | 10.68203 |
| DOCK1 | 1793 | 9.48097 | 11.021774 |
| MAPK1 | 5594 | 9.240688 | 9.218932 |
| ARHGEF7 | 8874 | 9.037083 | 9.147919 |
| CBLL1 | 79872 | 9.0251875 | 9.311203 |
| PKP2 | 5318 | 9.022291 | 10.025781 |
| BAIAP2 | 10458 | 9.018734 | 8.004229 |
| JAM2 | 58494 | 8.789471 | 8.162707 |
| CAV3 | 859 | 8.535716 | 8.229119 |
| ACTN2 | 88 | 8.437073 | 7.474538 |
| PKP1 | 5317 | 8.423988 | 7.3570046 |
| CDH3 | 1001 | 8.389479 | 7.50349 |
| CSF1 | 1435 | 8.360545 | 7.4550886 |
| TJP3 | 27134 | 8.295799 | 7.207067 |
| WASF1 | 8936 | 8.178464 | 7.4462004 |
| PVRL1 | 5818 | 8.152037 | 7.283169 |
| ESR1 | 2099 | 8.048168 | 7.405365 |
| OCLN | 100506658 | 8.036663 | 9.494983 |
| PIP5K1C | 23396 | 7.9606485 | 7.254657 |
| CTNND1 | 1500 | 7.8659673 | 7.09317 |
| MAP1B | 4131 | 7.7052383 | 10.589897 |
| DSG2 | 1829 | 7.513804 | 8.2605915 |
| CDH1 | 999 | 7.3595057 | 7.319695 |
| ACTN3 | 89 | 7.355976 | 6.6988516 |
| VCAN | 1462 | 7.045421 | 6.763195 |
| DLL1 | 28514 | 6.969655 | 6.5782347 |
| VPS13A | 23230 | 6.859817 | 10.562696 |
| DSG4 | 147409 | 6.608555 | 6.1116643 |
| DSC2 | 1824 | 6.3962626 | 7.24841 |
| INADL | 10207 | 6.08029 | 8.808925 |
| PNN | 5411 | 5.9342465 | 7.5790677 |
| APC | 324 | 5.3153567 | 6.5241365 |
| ITGA2 | 3673 | 6.538141 | 10.171594 |
| SORBS1 | 10580 | 6.5160394 | 7.080136 |
| SELE | 6401 | 5.8820415 | 7.629673 |
| ARHGAP5 | 394 | 5.628543 | 7.9602804 |
| ITGA1 | 3672 | 5.3547735 | 7.6031985 |
| ZEB2 | 9839 | 5.2203803 | 6.942315 |