Table 4.
Microarray analysis of tight junction–related gene expression regulation upon FH535 treatment
| Gene | ID | Normalized intensity
|
|
|---|---|---|---|
| Control | FH535 | ||
| RHOA | 387 | 15.761177 | 14.786651 |
| CLDN4 | 1364 | 15.11957 | 14.539507 |
| ACTN4 | 81 | 15.032014 | 14.01403 |
| CD44 | 960 | 15.006962 | 16.199093 |
| CAPN2 | 824 | 14.947017 | 15.841314 |
| TIMP2 | 7077 | 14.796619 | 14.858342 |
| CFL1 | 1072 | 14.710272 | 13.114106 |
| CSNK2B | 1460 | 14.4039135 | 14.575101 |
| RAC1 | 5879 | 14.251518 | 15.113209 |
| CTNNA1 | 1495 | 14.209974 | 14.654735 |
| MAPRE1 | 22919 | 13.413141 | 13.8757925 |
| ARHGDIA | 396 | 13.207352 | 11.634186 |
| EZR | 7430 | 13.144885 | 12.566931 |
| JAG1 | 182 | 12.427784 | 12.687155 |
| ACTN1 | 87 | 12.409878 | 11.967234 |
| TSPAN13 | 27075 | 12.246902 | 11.379381 |
| ILK | 3611 | 12.11682 | 11.583433 |
| ICAM1 | 3383 | 12.0056095 | 11.118488 |
| CLDN7 | 1366 | 11.972866 | 11.032687 |
| MMP1 | 4312 | 11.905035 | 12.887484 |
| CTNNB1 | 1499 | 11.900537 | 11.841962 |
| COL16A1 | 1307 | 11.647751 | 10.777789 |
| CSNK2A1 | 1457 | 11.389523 | 10.994029 |
| ENAH | 55740 | 11.354481 | 13.398125 |
| MLLT4 | 4301 | 11.299263 | 13.275789 |
| CDC42 | 998 | 11.250544 | 11.791042 |
| IGF1R | 3480 | 11.2369585 | 12.140446 |
| CLDN19 | 149461 | 11.222952 | 10.278006 |
| CTGF | 1490 | 10.809845 | 11.98555 |
| FZD7 | 8324 | 10.711324 | 9.901575 |
| MAPRE2 | 10982 | 10.535324 | 11.375724 |
| SVIL | 6840 | 10.304885 | 11.463148 |
| CLDN2 | 9075 | 10.221999 | 7.959734 |
| THBS3 | 7059 | 10.1687765 | 9.736564 |
| LIMK1 | 3984 | 10.151468 | 9.52237 |
| MPP5 | 64398 | 10.149654 | 12.064446 |
| TIAM1 | 7074 | 10.117085 | 11.627998 |
| CGN | 57530 | 10.004088 | 9.987757 |
| CSNK2A2 | 1459 | 9.960693 | 9.169151 |
| PRKCI | 5584 | 9.934886 | 11.633633 |
| CRKL | 1399 | 9.737389 | 9.574368 |
| TJAP1 | 93643 | 9.66933 | 9.609078 |
| CLDN12 | 9069 | 9.506469 | 10.83943 |
| TJP1 | 7082 | 9.28694 | 12.134832 |
| PARD6A | 50855 | 9.12321 | 8.362814 |
| ARHGEF7 | 8874 | 9.037083 | 9.147919 |
| PDPK1 | 5170 | 9.005413 | 9.698432 |
| CDH5 | 1003 | 8.708324 | 7.5856657 |
| LMO7 | 4008 | 8.558113 | 9.277104 |
| SPTAN1 | 6709 | 8.494044 | 7.7864056 |
| ACTN2 | 88 | 8.437073 | 7.474538 |
| CLDN9 | 9080 | 8.4181795 | 7.5940213 |
| CSF1 | 1435 | 8.360545 | 7.4550886 |
| TJP2 | 9414 | 8.343918 | 7.3491254 |
| HAS1 | 3036 | 8.124433 | 7.6573296 |
| CLDN16 | 10686 | 7.9999046 | 7.022292 |
| AMOTL1 | 154810 | 7.8963585 | 7.8100796 |
| CRK | 1398 | 7.5114365 | 8.404298 |
| ACTN3 | 89 | 7.355976 | 6.6988516 |
| PRKCG | 5582 | 7.321149 | 6.9112835 |
| CLDN6 | 9074 | 7.220466 | 6.6578355 |
| CLDN1 | 9076 | 7.1643777 | 8.943991 |
| CLDN15 | 24146 | 7.0927997 | 6.5795236 |
| CLDN10 | 9071 | 7.0557775 | 6.613464 |
| PTEN | 5728 | 7.0376005 | 9.120998 |
| SMAD2 | 4087 | 6.9688606 | 9.496367 |
| PARD3 | 56288 | 6.94016 | 7.33421 |
| CLEC3B | 7123 | 6.6491346 | 6.5587797 |
| SPP1 | 6696 | 6.37645 | 6.842924 |
| MAGI1 | 9223 | 6.3656254 | 7.168139 |
| CTTN | 2017 | 6.2022476 | 6.6959023 |
| ERBB3 | 2065 | 6.178696 | 5.9926624 |