Table 5.
Microarray analysis of cell motility–related gene expression regulation upon FH535 treatment
| Gene | ID | Normalized intensity
|
|
|---|---|---|---|
| Control | FH535 | ||
| VIM | 7431 | 18.111416 | 18.417988 |
| PERP | 64065 | 17.034954 | 17.530819 |
| MYH9 | 4627 | 16.01196 | 15.906586 |
| RHOA | 387 | 15.761177 | 14.786651 |
| ACTN4 | 81 | 15.032014 | 14.01403 |
| TIMP2 | 7077 | 14.796619 | 14.858342 |
| MSN | 4478 | 14.751841 | 15.357616 |
| CFL1 | 1072 | 14.710272 | 13.114106 |
| RAC1 | 5879 | 14.251518 | 15.113209 |
| RAP1B | 5908 | 14.023661 | 15.037672 |
| TIMP1 | 7076 | 13.919523 | 13.2338505 |
| CDK4 | 1019 | 13.87332 | 13.635977 |
| RHOC | 389 | 13.521647 | 12.094296 |
| LAMC1 | 3915 | 13.492421 | 14.51922 |
| VCL | 7414 | 13.376745 | 13.681126 |
| ACTR3 | 10096 | 13.228158 | 14.45616 |
| DIAPH1 | 1729 | 13.16062 | 13.659487 |
| EZR | 7430 | 13.144885 | 12.566931 |
| VAPA | 9218 | 13.089962 | 13.857084 |
| AKT1 | 207 | 12.957863 | 12.259176 |
| RAC2 | 5880 | 12.955015 | 11.604415 |
| ACTR2 | 10097 | 12.94824 | 13.651513 |
| ITGB1 | 3688 | 12.738785 | 13.636554 |
| PRKCZ | 5590 | 12.597843 | 11.836956 |
| ITGB2 | 3689 | 12.546266 | 11.473748 |
| ACTN1 | 87 | 12.409878 | 11.967234 |
| ILK | 3611 | 12.11682 | 11.583433 |
| SGCE | 8910 | 12.047686 | 12.282321 |
| ICAM1 | 3383 | 12.0056095 | 11.118488 |
| PPL | 5493 | 11.998627 | 11.51075 |
| PRKCA | 5578 | 11.918201 | 13.803304 |
| PPPDE2 | 27351 | 11.624274 | 11.774211 |
| ENAH | 55740 | 11.354481 | 13.398125 |
| CDC42 | 998 | 11.250544 | 11.791042 |
| EGFR | 1956 | 11.122326 | 12.333595 |
| WASL | 8976 | 10.930079 | 12.483249 |
| CALD1 | 800 | 10.921519 | 12.294691 |
| STEAP1 | 26872 | 10.895491 | 11.820029 |
| TGFB1 | 7040 | 10.7152 | 9.03388 |
| CAMK2N1 | 55450 | 10.587699 | 10.065469 |
| RDX | 5962 | 10.522251 | 12.191257 |
| MCAM | 4162 | 10.452353 | 9.462444 |
| ARF6 | 382 | 10.415711 | 11.52632 |
| SVIL | 6840 | 10.304885 | 11.463148 |
| RGS2 | 5997 | 10.257294 | 9.80196 |
| VEGFA | 7422 | 10.250756 | 7.901348 |
| CAPN1 | 823 | 10.239203 | 8.216266 |
| F11R | 50848 | 10.234683 | 9.044022 |
| RND3 | 390 | 10.199277 | 12.088578 |
| MMP2 | 4313 | 10.153262 | 9.412593 |
| WASF2 | 10163 | 10.085579 | 8.826545 |
| FAT1 | 2195 | 9.970972 | 12.042841 |
| RHOB | 388 | 9.965946 | 8.545685 |
| RAPGEF1 | 2889 | 9.903289 | 8.354535 |
| RASA1 | 5921 | 9.702747 | 11.502001 |
| PTK2B | 2185 | 9.636893 | 10.68203 |
| ROCK1 | 6093 | 9.603488 | 11.484902 |
| MYH10 | 4628 | 9.5496025 | 11.096066 |
| MMP15 | 4324 | 9.533566 | 8.395943 |
| DOCK1 | 1793 | 9.48097 | 11.021774 |
| PAK2 | 5062 | 9.287464 | 10.61245 |
| PLAUR | 5329 | 9.265003 | 8.37788 |
| CDC27 | 996 | 9.129515 | 11.077047 |
| MST1R | 4486 | 9.085802 | 9.12538 |
| BAIAP2 | 10458 | 9.018734 | 8.004229 |
| PTK2 | 5747 | 8.939062 | 10.820772 |
| STAT3 | 6774 | 8.847785 | 7.9192953 |
| ARHGEF2 | 9181 | 8.798216 | 8.383045 |
| PKP4 | 8502 | 8.663319 | 9.734335 |
| MARK2 | 2011 | 8.612933 | 8.00314 |
| PVRL3 | 25945 | 8.582907 | 9.851074 |
| BCAR1 | 9564 | 8.529809 | 7.7692404 |
| ARVCF | 421 | 8.524339 | 8.364944 |
| SPTAN1 | 6709 | 8.494044 | 7.7864056 |
| TJP2 | 9414 | 8.343918 | 7.3491254 |
| HCLS1 | 3059 | 8.263556 | 7.7210197 |
| WASF1 | 8936 | 8.178464 | 7.4462004 |
| HAS1 | 3036 | 8.124433 | 7.6573296 |
| ADAMTS13 | 11093 | 8.074093 | 8.375932 |
| ESR1 | 2099 | 8.048168 | 7.405365 |
| OCLN | 100506658 | 8.036663 | 9.494983 |
| WAS | 7454 | 7.9598556 | 7.412658 |
| CTNND1 | 1500 | 7.8659673 | 7.09317 |
| DOCK4 | 9732 | 7.829811 | 10.702755 |
| CDSN | 1041 | 7.738298 | 7.3062844 |
| MAP1B | 4131 | 7.7052383 | 10.589897 |
| MMP11 | 4320 | 7.460847 | 7.2920337 |
| PXN | 5829 | 7.426979 | 6.493304 |
| ACTN3 | 89 | 7.355976 | 6.6988516 |
| MTSS1 | 9788 | 7.3144355 | 8.826939 |
| VCAN | 1462 | 7.045421 | 6.763195 |
| MMP9 | 4318 | 7.0101504 | 6.7540355 |
| VTN | 7448 | 6.8925853 | 6.3992944 |
| EXOC2 | 55770 | 6.8692775 | 8.335709 |
| ECM1 | 1893 | 6.8224096 | 7.0186477 |
| TWIST1 | 7291 | 6.765423 | 6.105777 |
| ADAMTS1 | 9510 | 6.670437 | 7.5566187 |
| CASK | 8573 | 6.554297 | 9.147331 |
| PLCG1 | 5335 | 6.326862 | 6.175169 |
| CTTN | 2017 | 6.2022476 | 6.6959023 |
| FARP2 | 9855 | 5.4352922 | 5.775334 |
| CTNND2 | 1501 | 5.4170265 | 5.9111185 |