Table 6.
Microarray analysis of extracellular matrix degradation–related gene expression regulation upon FH535 treatment
| Gene | ID | Normalized intensity
|
|
|---|---|---|---|
| Control | FH535 | ||
| TGFBI | 7045 | 16.09069 | 15.894443 |
| TIMP2 | 7077 | 14.796619 | 14.858342 |
| TIMP1 | 7076 | 13.919523 | 13.2338505 |
| LAMC1 | 3915 | 13.492421 | 14.51922 |
| MMP1 | 4312 | 11.905035 | 12.887484 |
| COL16A1 | 1307 | 11.647751 | 10.777789 |
| COL5A1 | 1289 | 11.607744 | 10.272581 |
| COL6A1 | 1291 | 11.396863 | 10.174638 |
| LAMB1 | 3912 | 10.813978 | 9.924841 |
| CTGF | 1490 | 10.809845 | 11.98555 |
| THBS3 | 7059 | 10.1687765 | 9.736564 |
| MMP2 | 4313 | 10.153262 | 9.412593 |
| COL4A2 | 1284 | 9.866227 | 8.850218 |
| THBS1 | 7057 | 9.663341 | 9.193558 |
| MMP15 | 4324 | 9.533566 | 8.395943 |
| SPARC | 6678 | 9.32407 | 8.289816 |
| COL7A1 | 1294 | 8.711706 | 7.6560946 |
| LAMB3 | 3914 | 8.550647 | 8.319239 |
| HAS1 | 3036 | 8.124433 | 7.6573296 |
| ADAMTS13 | 11093 | 8.074093 | 8.375932 |
| SPG7 | 6687 | 7.799603 | 7.3888316 |
| MMP11 | 4320 | 7.460847 | 7.2920337 |
| COL12A1 | 1303 | 7.404812 | 8.422412 |
| COL14A1 | 7373 | 7.3424816 | 6.805993 |
| TNC | 3371 | 7.329479 | 6.564947 |
| VCAN | 1462 | 7.045421 | 6.763195 |
| MMP9 | 4318 | 7.0101504 | 6.7540355 |
| VTN | 7448 | 6.8925853 | 6.3992944 |
| ECM1 | 1893 | 6.8224096 | 7.0186477 |
| ADAMTS1 | 9510 | 6.670437 | 7.5566187 |
| CLEC3B | 7123 | 6.6491346 | 6.5587797 |
| SPP1 | 6696 | 6.37645 | 6.842924 |
| LAMA3 | 3909 | 6.1783895 | 5.889333 |