Table 8.
Microarray analysis of EMT-related gene expression regulation upon FH535 treatment
| Gene | ID | Normalized intensity
|
|
|---|---|---|---|
| Control | FH535 | ||
| VIM | 7431 | 18.111416 | 18.417988 |
| TGFBI | 7045 | 16.09069 | 15.894443 |
| NME1 | 4830 | 15.692858 | 15.573043 |
| IGFBP4 | 3487 | 14.852157 | 13.246835 |
| MSN | 4478 | 14.751841 | 15.357616 |
| RAC1 | 5879 | 14.251518 | 15.113209 |
| KRT7 | 3855 | 14.184294 | 13.285099 |
| TIMP1 | 7076 | 13.919523 | 13.2338505 |
| COL5A2 | 1290 | 13.175857 | 12.833253 |
| TCF3 | 6929 | 13.00084 | 12.29279 |
| AKT1 | 207 | 12.957863 | 12.259176 |
| ITGB1 | 3688 | 12.738785 | 13.636554 |
| CAV1 | 857 | 12.61244 | 13.617725 |
| SNAI1 | 6615 | 12.28132 | 10.385736 |
| ITGA5 | 3678 | 12.169847 | 10.866323 |
| TLN1 | 7094 | 12.096641 | 10.645829 |
| SYMPK | 8189 | 11.942529 | 12.312602 |
| CTNNB1 | 1499 | 11.900537 | 11.841962 |
| FXYD5 | 53827 | 11.859393 | 10.980669 |
| BMP7 | 655 | 11.688513 | 10.938241 |
| COL5A1 | 1289 | 11.607744 | 10.272581 |
| AHNAK | 79026 | 11.605762 | 10.785921 |
| CAV2 | 858 | 11.534644 | 11.731664 |
| NOTCH3 | 4854 | 11.523583 | 10.370972 |
| TLN2 | 83660 | 11.404076 | 10.886059 |
| COL6A1 | 1291 | 11.396863 | 10.174638 |
| KRT19 | 3880 | 11.289505 | 11.101922 |
| IGF1R | 3480 | 11.2369585 | 12.140446 |
| EGFR | 1956 | 11.122326 | 12.333595 |
| FYN | 2534 | 10.966112 | 11.325876 |
| WASL | 8976 | 10.930079 | 12.483249 |
| CALD1 | 800 | 10.921519 | 12.294691 |
| LAMB1 | 3912 | 10.813978 | 9.924841 |
| TGFB1 | 7040 | 10.7152 | 9.03388 |
| FZD7 | 8324 | 10.711324 | 9.901575 |
| SERPINE1 | 5054 | 10.639182 | 10.452353 |
| GRB2 | 2885 | 10.605613 | 9.416897 |
| RDX | 5962 | 10.522251 | 12.191257 |
| SVIL | 6840 | 10.304885 | 11.463148 |
| PLEC | 5339 | 10.301559 | 9.204668 |
| SHC1 | 6464 | 10.287678 | 8.595637 |
| RGS2 | 5997 | 10.257294 | 9.80196 |
| MMP2 | 4313 | 10.153262 | 9.412593 |
| SSX2IP | 117178 | 10.144432 | 11.167568 |
| COL4A2 | 1284 | 9.866227 | 8.850218 |
| PPAP2B | 8613 | 9.718731 | 9.956581 |
| THBS1 | 7057 | 9.663341 | 9.193558 |
| ESAM | 90952 | 9.472261 | 8.959825 |
| NOTCH4 | 4855 | 9.433491 | 9.707824 |
| SPARC | 6678 | 9.32407 | 8.289816 |
| VEZT | 55591 | 9.128493 | 11.195451 |
| MST1R | 4486 | 9.085802 | 9.12538 |
| STAT3 | 6774 | 8.847785 | 7.9192953 |
| ZAK | 51776 | 8.719432 | 11.337164 |
| COL7A1 | 1294 | 8.711706 | 7.6560946 |
| SMURF1 | 57154 | 8.629299 | 9.522539 |
| LAMB3 | 3914 | 8.550647 | 8.319239 |
| TNS1 | 7145 | 8.064375 | 7.5303655 |
| SPG7 | 6687 | 7.990712 | 6.850328 |
| SOS1 | 6654 | 7.9648976 | 7.5355105 |
| WIPF1 | 7456 | 7.8996034 | 7.0742846 |
| BMP1 | 649 | 7.73736 | 6.776738 |
| FOXC2 | 2303 | 7.5557323 | 6.690961 |
| COL12A1 | 1303 | 7.404812 | 8.422412 |
| CDH1 | 999 | 7.3595057 | 7.319695 |
| COL14A1 | 7373 | 7.3424816 | 6.805993 |
| TNC | 3371 | 7.329479 | 6.564947 |
| IL1RN | 3557 | 7.2758436 | 6.734858 |
| SOX10 | 6663 | 7.0939784 | 6.8492174 |
| VCAN | 1462 | 7.045421 | 6.763195 |
| PTEN | 5728 | 7.0376005 | 9.120998 |
| MMP9 | 4318 | 7.0101504 | 6.7540355 |
| MPP6 | 51678 | 6.9906545 | 8.912582 |
| SYK | 6850 | 6.4246235 | 6.223468 |
| SPP1 | 6696 | 6.37645 | 6.842924 |
| ERBB3 | 2065 | 6.178696 | 5.9926624 |
| LAMA3 | 3909 | 6.1783895 | 5.889333 |
| BMP2 | 650 | 6.0141077 | 7.1390386 |
| SOS2 | 6655 | 5.6132765 | 8.797646 |
| TGFB3 | 7043 | 5.5891886 | 6.0552535 |
Abbreviation: EMT, epithelial–mesenchymal transition.