Table 9.
Microarray analysis of cell cycle–related gene expression regulation upon 20 μM FH535 treatment
| Gene | ID | Normalized intensity
|
|
|---|---|---|---|
| Control | FH535 | ||
| MYC | 4609 | 16.268158 | 15.204586 |
| CKS2 | 1164 | 15.878164 | 15.394571 |
| RHOA | 387 | 15.761177 | 14.786651 |
| BIRC5 | 332 | 14.757564 | 14.219355 |
| CCNB1 | 891 | 14.478785 | 14.022737 |
| CCNB2 | 9133 | 14.019871 | 14.271269 |
| KPNA2 | 3838 | 13.950185 | 14.971469 |
| CDK4 | 1019 | 13.87332 | 13.635977 |
| CDKN2D | 1032 | 13.839806 | 12.513427 |
| GADD45A | 1647 | 13.765451 | 13.130958 |
| CDKN1C | 1028 | 13.694702 | 12.537176 |
| PCNA | 5111 | 13.611973 | 13.2414665 |
| CKS1B | 1163 | 13.609195 | 12.845673 |
| MCM3 | 4172 | 13.580797 | 13.911951 |
| PRC1 | 9055 | 13.4114275 | 14.32471 |
| MAD2L1 | 4085 | 13.297964 | 12.867024 |
| CDK1 | 983 | 13.286596 | 13.600226 |
| DDIT3 | 1649 | 13.135856 | 11.871853 |
| SERTAD1 | 29950 | 13.060848 | 11.212 |
| IGF2 | 3481 | 13.0203 | 13.799717 |
| AKT1 | 207 | 12.957863 | 12.259176 |
| GNL3 | 26354 | 12.891848 | 14.223899 |
| ITGB1 | 3688 | 12.738785 | 13.636554 |
| RASSF1 | 11186 | 12.559567 | 11.458946 |
| CDK7 | 1022 | 12.553116 | 13.288865 |
| CDC34 | 997 | 12.53036 | 11.302476 |
| TFDP2 | 7029 | 12.527303 | 12.6644745 |
| CDC20 | 991 | 12.526335 | 11.232994 |
| CDKN3 | 1033 | 12.486179 | 12.966997 |
| MAP2K1 | 5604 | 12.483637 | 11.714967 |
| CUL3 | 8452 | 12.389215 | 13.715795 |
| FOSL1 | 8061 | 12.344017 | 11.102832 |
| ILK | 3611 | 12.11682 | 11.583433 |
| FOXO3 | 2309 | 12.095011 | 13.865094 |
| MNAT1 | 4331 | 12.074865 | 12.456777 |
| JUN | 3725 | 12.038464 | 12.673436 |
| PDK2 | 5164 | 11.944916 | 10.781894 |
| CTNNB1 | 1499 | 11.900537 | 11.841962 |
| WEE1 | 7465 | 11.894105 | 13.381722 |
| MCM2 | 4171 | 11.862871 | 11.269842 |
| AURKB | 9212 | 11.800928 | 9.697033 |
| PPP1R15A | 23645 | 11.676006 | 10.124018 |
| MDC1 | 9656 | 11.649198 | 10.940614 |
| CDKN2C | 1031 | 11.6150875 | 11.096327 |
| CCND3 | 896 | 11.576098 | 10.075832 |
| CCNE1 | 898 | 11.407219 | 11.045229 |
| CDKN2A | 1029 | 11.343829 | 11.097562 |
| AURKA | 6790 | 11.181647 | 10.961699 |
| RAD1 | 5810 | 11.162613 | 9.890079 |
| NOTCH2 | 4853 | 11.125797 | 10.202223 |
| EGFR | 1956 | 11.122326 | 12.333595 |
| CDK5 | 1020 | 11.117936 | 10.542482 |
| RAD51 | 5888 | 11.1082325 | 10.784544 |
| CCNA2 | 890 | 10.911861 | 10.9871645 |
| MCM4 | 4173 | 10.849212 | 11.05679 |
| CDC16 | 8881 | 10.808938 | 13.084003 |
| BCCIP | 56647 | 10.778181 | 12.021907 |
| CDC25C | 995 | 10.672214 | 10.564099 |
| RB1 | 5925 | 10.640414 | 12.741512 |
| CCNC | 892 | 10.610059 | 10.50804 |
| CDK9 | 1025 | 10.606858 | 9.6394415 |
| GRB2 | 2885 | 10.605613 | 9.416897 |
| ATM | 472 | 10.5960865 | 9.790577 |
| PPM1D | 8493 | 10.580978 | 9.338833 |
| CCND1 | 595 | 10.543621 | 10.14267 |
| PKD1 | 5310 | 10.471296 | 9.29677 |
| E2F3 | 1871 | 10.412796 | 12.061844 |
| CCNG1 | 900 | 10.409301 | 9.063653 |
| CDK5R1 | 8851 | 10.322197 | 10.292204 |
| PDK1 | 5163 | 10.321034 | 10.933424 |
| MAD2L2 | 10459 | 10.306548 | 9.040705 |
| SHC1 | 6464 | 10.287678 | 8.595637 |
| CCNT1 | 904 | 10.17827 | 11.456285 |
| CDK2 | 1017 | 10.10528 | 9.357359 |
| RUVBL1 | 8607 | 10.000026 | 8.814938 |
| SKP2 | 6502 | 9.937107 | 8.872935 |
| CASP3 | 836 | 9.893856 | 10.658698 |
| AHR | 196 | 9.886938 | 11.936481 |
| RAD9A | 5883 | 9.855825 | 8.961951 |
| PA2G4 | 5036 | 9.737894 | 8.966842 |
| CHEK2 | 11200 | 9.726725 | 10.255492 |
| INS | 3630 | 9.673779 | 8.813154 |
| BBS4 | 585 | 9.597437 | 9.65494 |
| SIAH1 | 6477 | 9.530121 | 9.295226 |
| CCNG2 | 901 | 9.4692955 | 8.337656 |
| RBBP8 | 5932 | 9.454372 | 12.631638 |
| MAPK3 | 5595 | 9.447224 | 7.818405 |
| TFDP1 | 7027 | 9.4434185 | 9.030092 |
| E2F1 | 1869 | 9.397123 | 8.754342 |
| CDK5RAP2 | 55755 | 9.390803 | 10.79269 |
| MAPK1 | 5594 | 9.240688 | 9.218932 |
| MKI67 | 4288 | 9.233824 | 8.092867 |
| ID2 | 3398 | 9.226584 | 8.999163 |
| CUL1 | 8454 | 9.221058 | 10.794849 |
| RBL2 | 5934 | 9.160267 | 10.348637 |
| JAG2 | 3714 | 9.075178 | 8.140677 |
| GTSE1 | 51512 | 9.04477 | 8.488665 |
| CHEK1 | 1111 | 9.04231 | 9.651725 |
| E2F4 | 1874 | 9.035055 | 8.016477 |
| G0S2 | 50486 | 9.032754 | 8.410861 |
| SESN2 | 83667 | 8.951754 | 8.138044 |
| PTK2 | 5747 | 8.939062 | 10.820772 |
| CDC25A | 993 | 8.677163 | 8.042739 |
| MDM2 | 4193 | 8.622698 | 7.73673 |
| CDK5RAP1 | 51654 | 8.508385 | 6.9220624 |
| AXIN1 | 8312 | 8.351635 | 7.6164603 |
| ATR | 545 | 8.152882 | 11.634625 |
| MCM5 | 4174 | 8.055058 | 7.4200873 |
| CDKN1A | 1026 | 8.007444 | 6.7135 |
| SOS1 | 6654 | 7.9648976 | 7.5355105 |
| CDKN1B | 1027 | 7.8906517 | 6.7354736 |
| GML | 2765 | 7.8596773 | 6.9595275 |
| TSC1 | 7248 | 7.6562896 | 9.700143 |
| BRCA1 | 672 | 7.620017 | 10.24544 |
| CUL2 | 8453 | 7.566332 | 9.5496025 |
| STMN1 | 3925 | 7.5155845 | 6.8102884 |
| CDK8 | 1024 | 7.5133963 | 6.9160185 |
| TERT | 7015 | 7.4070444 | 7.4882307 |
| ABL1 | 25 | 7.3099413 | 6.6226487 |
| PTEN | 5728 | 7.0376005 | 9.120998 |
| MDM4 | 4194 | 6.996299 | 8.63818 |
| HUS1 | 3364 | 6.976554 | 7.3689637 |
| RBL1 | 5933 | 6.7265186 | 8.035306 |
| CCND2 | 894 | 6.3239446 | 5.996339 |
| BMP2 | 650 | 6.0141077 | 7.1390386 |
| ATRIP | 84126 | 5.912352 | 6.682503 |
| CDC6 | 990 | 5.8019896 | 6.064807 |
| SOX2 | 6657 | 5.6166873 | 6.7975965 |
| PTGS2 | 5743 | 5.5262737 | 7.601541 |
| APC | 324 | 5.3153567 | 6.5241365 |
| BTRC | 8945 | 5.3152456 | 7.7473273 |