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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Arch Biochem Biophys. 2015 May 23;579:1–7. doi: 10.1016/j.abb.2015.05.005

Figure 1.

Figure 1

The flow of reducing equivalents during the oxidation of a protein dithiol catalyzed by Mia40 and lfALR. Mia40 (PDB 2K3J) is reduced by a reduced substrate (step 1) and then communicates with the distal CxxC disulfide in one subunit of homodimeric lfALR (step 2). Step 3 depicts intersubunit thiol-disulfide exchange, generating the reduced proximal disulfide, followed by transfer of reducing equivalents to the FAD prosthetic group (step 4). Oxidation is completed by reduction of cytochrome c or molecular oxygen (step 5).