. Author manuscript; available in PMC: 2016 Aug 15.

Published in final edited form as: J Neurosci Methods. 2015 May 18;251:120–129. doi: 10.1016/j.jneumeth.2015.05.006

Table 2. Whole tissues levels of DA and DA metabolites in unilaterally 6-OHDA lesioned rats after repeated intranasal administration of DNSP-11.

Individual analyte levels (ng/g – wet tissue weight) of the contralateral (unlesioned) and ipsilateral (lesioned) striatum. DA turnover [(DOPAC + HVA)/DA] ratios were analyzed by a one-way ANOVA with Bonferroni’s post-hoc test

Brain Region	Neurochemical Analyte	Intranasal Treatment		one-way ANOVA
Brain Region	Neurochemical Analyte	Vehicle (ng/g)	300 μg DNSP-11 (ng/g)	one-way ANOVA
Unlesioned Striatum	DA	10304±1104	12299±555
	DOPAC	2807±457	2422±241
	HVA	759±44	861±49
	(DOPAC+HVA)/DA	0.341±0.047	0.257±0.024	P<0.0001 F_(3,24)=24.56
Lesioned Striatum	DA	123±46	201±171
	DOPAC	60±19	58±46
	HVA	18±7	21±20
	(DOPAC+HVA)/DA	0.884±0.074	^^0.538±0.062	P<0.0001 F_(3,24)=24.56

p < 0.05. Intranasal administration of DNSP-11 resulted in a decrease in DA turnover in the lesioned striatum, suggestive of a protective effect on the DA system. All data are presented as mean ± SEM, n = 8 vehicle and n = 6 DNSP-11 treated.