Fig. 1.

Mitochondrial quality control. The key events associated with mitochondrial dynamics and mitophagy affecting the mitochondrial quality control are depicted here. Under normal physiological conditions, the mitochondria are usually tubular (A). Physiological stress induces mitochondrial injury and causes mitochondrial impairment (B). The impaired part of the mitochondria is segregated by the fission process (C). The impaired mitochondria are selectively flagged by the PINK1 (D) that facilitates Parkin recruitment and mitophagy (E). All the repaired mitochondria are recruited to the functional mitochondrial network by fusion with other mitochondria (F). The factors that orchestrate the fission, fusion and mitophagy activities are shown in the inset.